Endocrine Abstracts

Introduction: There is an association between Moyamoya syndrome and Graves’ disease, described primarily in Asian populations. We report a case of Moyamoya vasculopthy with stroke and hypertension associated with graves’ disease in a 15-year-old Tunisian girl.Observation: A 15-year-old girl diagnosed with Moyamoya vasculopathy was referred to the endocrinology department for hyperthyroidism. The patient had a history of recurrent stroke and hyp...

Introduction: Hypothyroidism is a common endocrine disease with reduced systemic metabolism and its treatment consists on hormonal supplementation. However, despite concurrent replacement therapy with high doses of L-thyroxin, some patients might be seen with clinical and biochemical evidence of hypothyroidism. We report a case of persistent hypothyroidism on high dose of levothyroxin.Case presentation: It was a 41-year-old female, with a history of recu...

Introduction: Dopamine agonists, mainly cabergoline and bromocriptine, represent the first-line treatment option in the management of prolactinomas. They allow prolactin normalization and tumor shrinkage. However, a subset of individuals with macroprolactinoma could exhibit a varying degree of resistance to dopamine agonists. The aim of this study was to determine the prevalence of dopamine agonist-resistance in patients with macroprolactinoma and to assess its predictive fact...

Introduction: Surgical treatment is indicated in patients with dopamine agonist-resistant macroprolactinoma. However, the resection of the tumor is usually partial because of fibrotic changes under long-term dopamine agonist therapy. Thus, early identification and management of patients at high risk of dopamine agonist resistance is crucial to a complete resection outcome and a better remission. The aim of this study was to develop a score predicting dopamine agonist resistanc...

Introduction: Statins are widely used to prevent cardiovascular diseases. Nonetheless, reducing cholesterol, the main substrate for steroidogenesis, may impair cortisol production. The aim of our study was to assess the effect of high dose statin therapy on cortisol and dehydroepiandrosterone-sulphate (DHEA-S) levels in type 2 diabetes male patients.Methods: This was a single-center, prospective study, during the period march 2021 - July 2022, including ...

Introduction: Statins are widely used in primary and secondary cardiovascular prevention. They have been described to improve renal function. We aimed in this study to evaluate the effect of high dose atorvastatin therapy on renal outcome in type 2 diabetes patients.Methods: This was a single-center, prospective study, including 60 men with type 2 diabetes mellitus, aged between 40 and 65 years, statin-free, in whom the indication of a high dose statin t...

Introduction: The diagnosis of primary hyperparathyroidism and hypoparathyroidism is still challenging because of the increasing frequency of non-classical presentations. The calcium-to-phosphorus ratio (Ca/P) (CPR) is an inexpensive biochemical marker that could be useful to diagnose parathyroid disorders.Aim: The aim of this study was to assess the performances of CPR in the diagnosis of primary hyperparathyroidism and hypoparathyroidism.<p class="...

Introduction: Primary hyperparathyroidism is a common endocrine disease. Its association with inflammatory and thrombotic events was rarely reported in the literature. The pathophysiological mechanisms of this association remain uncertain. Herein, we report a case of hypercalcemia secondary to primary hyperparathyroidism revealed by a deep vein thrombosis.Observation: A 65-year-old patient was referred to our department for primary hyperparathyroidism. T...

Introduction: Patients with type 2 diabetes mellitus are considered at least at high cardio-vascular risk. Cardiovascular risk factors must be regularly screened. Hyperhomocysteinemia is considered as an independent risk factor for atherosclerotic disease and coronary disease in some studies. The aim of our study was to confirm the association between hyperhomocysteinemia and atherosclerotic disease in patients with type 2 diabetes.Methods: We performed ...

Introduction: Endocrine complications are common in beta thalassemia major (BTM) patients receiving blood transfusions. Chelation therapy has a role in preventing such complications. However, patients may have difficulties adhering to chelation therapy. We aimed in this study to determine the endocrine complications in BTM patients.Methods: This was a descriptive study with cross-sectional data collection over a 6 month period from February 2022 to July ...